cross-talk between endothelin-1 and mineral metabolism in hemodialysis patients: a cross-sectional study
نویسندگان
چکیده
conclusions serum p and ipth levels were independently associated with et-1 and those may play a role in development of endothelial dysfunction in chronic kidney disease. patients and methods in this cross-sectional study, 46 chronic stable hd patients were selected from nephrology departments of tabriz university of medical sciences affiliated hospitals and classified based on phosphorus (p), ca-p product (ca × p) and intact parathyroid hormone (ipth) levels. we evaluated fasting serum et-1and hs-crp levels by the standard methods and compared with 46 healthy control subjects. results the levels of serum hs-crp and et-1 were significantly higher in the patient’s group compared with controls (4.40 ± 1.26 vs. 1.38 ± 1.61, p ˂ 0.0001, and 2.31 ± 0.87 vs. 0.75 ± 0.48, p ˂ 0.0001, respectively) and with regard to ca × p product cut-off point (3.99 ± 0.78 vs. 5.33 ± 1.64, p ˂ 0.0001, and 2 ± 0.73 vs. 3.04 ± 0.73, p ˂ 0.0001 respectively). et-1 was correlated significantly with hs-crp level (r = 0.776, p ˂ 0.0001). serum p, ca × p and ipth levels directly and ca indirectly were correlated with serum et-1 in hd patients (r = 0.932, p < 0.0001, r = 0.766, p ˂ 0.0001, r = 0.514, p ˂ 0.0001, r = -0.538, p ˂ 0.0001 respectively). multiple regression analysis demonstrated that serum p were independently associated with et-1 levels (β = 0.932, p ˂ 0.0001). background endotheline-1 (et-1), an endothelial mediator, influences on mineral metabolism; especially vascular calcification in uremic patients. objectives the aim of the present study was to evaluate of et-1, high-sensitivity c-reactive protein (hs-crp) and mineral metabolites as the main factors for vascular calcification and inflammation in hemodialysis (hd) patients.
منابع مشابه
Cross-Talk Between Endothelin-1 and Mineral Metabolism in Hemodialysis Patients: A Cross-Sectional Study
BACKGROUND Endotheline-1 (ET-1), an endothelial mediator, influences on mineral metabolism; especially vascular calcification in uremic patients. OBJECTIVES The aim of the present study was to evaluate of ET-1, high-sensitivity C-reactive protein (hs-CRP) and mineral metabolites as the main factors for vascular calcification and inflammation in hemodialysis (HD) patients. PATIENTS AND METHO...
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عنوان ژورنال:
iranian red crescent medical journalجلد ۱۶، شماره ۶، صفحات ۰-۰
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